関連する実験動画

Updated: Sep 9, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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トランスクリプト同型多様性は,ロングリードシーケンシングによる急性骨髄性白血病の分子サブタイプと予後を定義する

Xiaoguang Shi1, Shuai Wang2, Shuting Yu2

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Cell reports
|September 4, 2025
PubMed
まとめ

ロングリードシーケンシングでは,急性骨髄性白血病 (AML) の新しいトランスクリプト同型が発見され,広範なスプライシング異常が発見されました. これらの発見は,患者の予後に関連した新しいAMLサブタイプを定義し,精密医療への道を切り開きます.

キーワード:
CP: がんについてCP:ゲノミクス急性骨髄性白血病代替スプライシングロングリードRNAシーケンシング分子型負でない行列の因数分解トランスクリプト アイソフォーム

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