Mpoxワクチン接種後の急性後部多焦点性プラコイド色素性上皮炎のような炎症
Lucy M Lu1,2, Priya D Samalia1,3,4, Rachael L Niederer1,2
1Department of Ophthalmology, Te Whatu Ora Te Toka Tumai/Health New Zealand Auckland, Auckland, New Zealand.
Ocular immunology and inflammation
|September 4, 2025
まとめ
ポポックスワクチン接種後,急性後部多焦点性プラコイド色素性上皮炎 (APMPPE) のようなパヌヴェイチスが発生した. コルチコステロイド治療で症状が解消し,ワクチンに関連した目の合併症の可能性を強調した.
科学分野:
- 眼科について
- ワクチン学
- 免疫学
背景:
- 特にJYNNEOSのワクチン接種は公衆衛生にとって極めて重要です.
- 眼の炎症には様々な原因がある.
- ワクチンに関連した有害事象のスペクトルは,継続的に記録されています.
研究 の 目的:
- 脊髄炎の1例を記録し,脊髄炎ワクチン接種後の急性後部多焦点性プラコイド性皮質病 (APMPPE) に似ています.
- モポックスワクチン接種とこの特定の眼炎症の関連性を調査する.
主な方法:
- ケースレポートの方法論が採用された.
- 臨床表現,マルチモダルイメージング (OCTと fundus autofluorescenceを含む),および感染症/全身的原因の排除が詳細に示されました.
- コルチコステロイドに対する治療反応をモニターした.
主要な成果:
- JYNNEOS mpoxのワクチン接種から2週間後,37歳の男性に双方のウエビチス,網膜血管炎,および片方のAPMPPEのような特徴が発症しました.
- 感染性および全身性炎症の原因は排除された.
- 患者は局所および全身用コルチコステロイドで臨床的に有意な改善を示し,9ヶ月間にわたって再発しなかった.
結論:
- 急性後部多焦点性プラコイド色素上皮病 (APMPPE) のようなパヌヴェイチス (panuveitis) は,ポポックスワクチン接種後の潜在的な,しかし稀な,眼部合併症です.
- 眼科医や医療従事者は,ワクチン接種後の類似したウエウィト症候群を有する患者にこの診断を考慮すべきである.
- 早期診断とコルチコステロイドによる治療は,好ましい視覚的結果をもたらすことができます.
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