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Updated: Sep 9, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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ガン治療のための二重EGFRと炭酸アンヒドラゼ阻害剤としての新しいスルファモイルフェニル-二水素-チアジアゾール誘導体

Ibrahim H Eissa1, Hazem Elkady1, Walid E Elgammal2

  • 1Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

PloS one
|September 4, 2025
PubMed
まとめ

新しい化合物である化合物14は,EGFRとヒト炭酸水素酸 (hCA_IX,hCA_XII) を効果的に抑制する. 選択的な癌細胞毒性と好ましい安全性プロファイルを示し,有望な薬候補となります.

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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

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