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Updated: Sep 9, 2025

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
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An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

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ヘテロプラズマのmtDNA変異の蓄積による生理的回復力の可逆的妥協

Huihui Huang1, Yi Wang2, Zsuzsanna K Zsengeller1

  • 1Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Science (New York, N.Y.)
|September 4, 2025
PubMed
まとめ

暫定的な損傷は持続的なミトコンドリアDNA (mtDNA) 変異を引き起こし,細胞のエネルギーと回復力を損なう. 核制御されたピューリン生物合成によるアデノシン濃度の回復は,ATP生成と腎臓の健康を改善することができます.

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