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水消毒副産物と先天性欠陥との関連を調べるために,毒理学的に情報を得た相対的効能因子の適用

John A Kaufman¹, Michael G Narotsky², Glenn E Rice³

¹Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States.

Environmental science & technology

|September 4, 2025

まとめ

毒理学的に知られた相対効力因子 (RPF) は,無重量化消毒副産物 (DBP) の測定が,飲料水汚染物質による先天性欠陥のリスクを合理的に推定することを示唆しています. 個別レベルのデータによるさらなる研究が推奨されます.

科学分野:

環境健康
毒理学について
流行病学

背景:

飲料水中の消毒副産物 (DBP) は,出生に悪影響を及ぼします.
複雑なDBP混合物からのリスクを評価するには,個々の化合物の効能を理解する必要があります.

研究の目的:

相対的効力因子 (RPF) と非重量化消毒副産物 (DBP) の混合和を用いた先天性欠陥の流行病学的分析を比較する.
特定の先天性欠陥のリスク評価に対する毒理学的データの影響を評価する.

主な方法:

トライハロメタン (THM) とハロアセティック酸 (HAA) の動物バイオアッセイから派生したRPF
5つの先天性欠陥に対するRPF加重と未加重の確率比 (aORs)
pondered と unweighted の間の aOR の変化を比較した.

主要な成果:

RPFはブロム化DBPではより高く,より高い効力を示した.
RPFの加重は,THM混合物 (TOF) を除いて,aORを最小限に変化させた.
特定のHAA混合物と先天性欠陥 (例えばASD,TOF,OGD) に対して,aORの有意な変化 (> 10%) が観察されました.

結論:

規制されたDBPに対するリスクの見積もりを,未加重のDBPメトリックが提供できる.
RPFの重み付けは,特に特定の混合物や結果について,リスク評価を洗練することができます.
将来の研究における測定誤差を減らすために,個人レベルの暴露データは極めて重要です.

キーワード:

生まれつきの欠陥化学混合物生まれつきの異常暴露の評価ハロアセチン酸相対的な効能因子テラトゲントライハロメタン

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