関連する実験動画

Updated: Sep 9, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

15.6K

本質的に乱れたタンパク質の分子ダイナミクス COR15A─A 構造とダイナミクスの力場検証

Tobias Rindfleisch1,2,3,4, Ricky Nencini5,6, O H Samuli Ollila5,7

  • 1Computational Biology Unit, Department of Informatics, University of Bergen, 5008 Bergen, Norway.

Journal of chemical theory and computation
|September 4, 2025
PubMed
まとめ

本質的に無秩序なタンパク質 (IDP) の20の分子動力学モデルを評価した. DES-amberはCOR15Aタンパク質のダイナミクスを最もよくシミュレートし,IDPの研究における正確な力場の必要性を強調しました.

さらに関連する動画

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

521
Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.1K

関連する概念動画

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.2K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

2.4K
Protein Folding01:22

Protein Folding

Overview
120.7K
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
7.0K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
915
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

13.2K