肥満の子供の微生物群の生態は,炭水化物の摂取とインスリン抵抗性に関連しています

Flavia Prodam¹, Roberta Ricotti², Alice Caramaschi³

¹Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy; Unit of Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.

Clinical nutrition (Edinburgh, Scotland)

|September 4, 2025

まとめ

食中の炭水化物の摂取とインスリン抵抗性は,肥満児の腸内微生物群に大きく影響します. これらの関連性を理解することは青春期や性別などの要因を考慮して効果的な小児肥満治療の開発に不可欠です

科学分野:

小児内分泌学
微生物群の研究
栄養学

背景:

食事と腸内微生物群と肥満の相互作用は複雑で未熟です
子供の肥満はしばしば内臓脂肪および代謝変化と関連しています.

研究の目的:

肥満や過体重の小児患者の食事の組成と腸内微生物群の関係を調査する.
地中海食の介入前に基線微生物群のプロファイルを確立する.

主な方法:

肥満/肥満の55人の小児科 (10~18歳) の表型特徴
腸内微生物群のプロファイリングのための16S rRNA遺伝子配列化.
ライフスタイル,食事 (KIDMED,24時間リコール),身体活動,およびLPSレベルを含む臨床パラメータの評価.

主要な成果:

5つの異なる腸型が特定され,細菌群の組成は思春期の進行によって変化した.
炭水化物の摂取割合とインスリン抵抗性は,腸内微生物群の主要な調節因子でした.
特定の細菌種は,炭水化物の摂取量,繊維の摂取量,およびインスリン抵抗性のレベルと関連していました.

結論:

食中の炭水化物含有量,インスリン抵抗性,腸内微生物群は肥満の子どもでは複雑に結びついています
ディスバイオシスは,小児集団における重度の肥満現象に寄与する可能性があります.
性別や思春期の状態は子どもの微生物群を標的とした介入を複雑にします

キーワード:

炭水化物ダイエットインスリン抵抗性微生物群肥満小児科

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