関連する実験動画

Updated: Sep 9, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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選択的デルタオピオイド受容体アゴニストとしてのノールセバインの新型パラ置換フェニラミノおよびフェニル誘導体の設計,合成および生物学的活性

Denggao Zhang1, Jiangwen Gui2, Linghui Kong1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China.

Bioorganic & medicinal chemistry
|September 4, 2025
PubMed
まとめ

研究者は,構造ベースの設計を使用して,新しい非ペプチドルデルタオピオイド受容体 (DOR) アゴニストを開発しました. これらの化合物はDORに対する高い選択性を示し,より安全な鎮痛薬のための有望な戦略を提供します.

キーワード:
4,5-エポキシモルフィナンDOR選択性アゴニスト構造と活動の関係

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