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Updated: Sep 9, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

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クロストリディアルに支配された腸内微生物群は,コレスタシス治療において,オベチコル酸をリトコル酸に7α-デヒドロキシル化を促進する

Yuxuan Zhang1, Zhou Zhou1, Yunshu Li1

  • 1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No.163 Xianlin Avenue, Nanjing 210023, China.

Biochemical and biophysical research communications
|September 4, 2025
PubMed
まとめ

肝疾患におけるオベチコール酸 (OCA) の毒性は,それを有毒な代謝産物に変換する腸内細菌と関連している. 腸内微生物を調節することで,OCAを減らすことができる.

キーワード:
7α-脱水酸化コレスタシスクロストリジウム,胆酸誘導 (Bai)LCAOCA

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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