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サキュラネチンは骨格形成を阻害し,PI3K/ AKTとNF- kBのシグナル伝達経路を阻害することで,卵巣切除による骨の損失を救います

Beiduo Shen1, YingYing Du2, Runqi Wang2

  • 1Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China.

International immunopharmacology
|September 4, 2025
PubMed
まとめ

サキュラネチン (Sak) は,NF- kBとPI3K/ AKTのシグナル伝達を抑制することで,骨格形成と骨の再吸収を阻害する. この天然のフラボノイドは,骨粗鬆症と骨格の非鉱化に治療的可能性を示しています.

キーワード:
NF-κB についてオステオクラスト骨粗鬆症PI3K/AKTサクラネチン

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