関連する実験動画

Updated: Sep 9, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

172

リウマチ性関節炎に対するディターペノイドアルカリドポリスチスティンDの緩和効果とメカニズムを,ネットワーク薬理学と非標的メタボロミクスに基づいて調べる

Ya-Zhao Zhang1, Wen-Jing Li1, Zhi-Kang Chen1

  • 1Teaching and Research Department of Chinese Materia Medica Resources, College of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.

International immunopharmacology
|September 4, 2025
PubMed
まとめ

ポリキスティンD (PD) は,関節炎を軽減し,軟骨と骨の損傷から保護することで,関節リウマチ (RA) を効果的に治療します. そのメカニズムは,JAK/STATとPI3K/Akt/mTORのような重要なシグナル伝達経路を阻害することです.

キーワード:
JAK/STATネットワーク薬理学非標的メタボロミクスPI3K/Akt/mTOR についてポリキスティンDリウマチ性関節炎

さらに関連する動画

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

540
Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

896

関連する概念動画

Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
9.2K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.2K