エクストラ・バージン・オリーブオイルとPREDIMED試験における追加的な心血管的アウトカム:アウトカム・ワイド・パースペクティブ
Javier Pérez de Rojas1, Estefania Toledo2, Ramón Estruch3
1Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain..
American heart journal
|September 4, 2025
まとめ
ポリフェノールに富んだエクストラ・バージン オリーブオイル (EVOO) の高い消費量は,心血管疾患 (CVD) のリスクを大幅に低下させます. 普通のオリーブオイル (COO) は,心臓の健康にEVOOの重要性を強調して,有意な利益を示さなかった.
科学分野:
- 心血管の健康
- 栄養学的流行病学
- 予防医学
背景:
- オリーブ油の摂取は,心血管疾患 (CVD) のリスクの低下と関連しています.
- 以前の研究では,エクストラ・バージン・オリーブオイル (EVOO) とコモン・オリーブオイル (COO) の詳細な区別がありませんでした.
- 限られた研究で,広範なCVDのアウトカムが評価されたり,繰り返し食事の評価が使用されたりしました.
研究 の 目的:
- EVOOとCOOの消費と幅広いCVDのアウトカムの関連性を評価する.
- 高リスクの個体における心血管疾患リスクに対する 累積的なオリーブオイル摂取の影響を調査する.
- EVOOとCOOのCVD予防効果を区別する
主な方法:
- PREDIMED試験の7,102人の高リスク被験者の分析.
- EVOOとCOOの累積平均摂取量を計算したオリーブオイル消費量の年次評価
- 時間依存のコックスモデルは,複合CVDアウトカム (心筋梗塞,脳卒中,PAD,心不全,AFib,またはCV死亡) と個々のイベントを評価するために使用されました.
主要な成果:
- EVOOの摂取量の最も高い3分の1は,CVDの複合的な結果の25%低いリスクと関連している (HR: 0.75).
- EVOOの摂取量の最も高いデシールと最も低いデシールは,48%のリスク低下を示した (HR:0. 52).
- COOの消費は,EVOOに相互調整された場合,CVDリスクと有意に関連しませんでした (HR: 10g/日あたり0. 93).
結論:
- EVOOの高消費は,高リスクの個人にCVDの複合的な結果のリスクを大幅に軽減します.
- ポリフェノールが欠けていたCOOは,CVDリスクの減少とより弱い関連性を示した.
- 効果的なCVD予防戦略には,オリーブ油の種類,特にEVOOの区別が不可欠です.
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