サクラロースの摂取は,健康な個体におけるグルコースホメオスタシス,腸内微生物群,Curliタンパク質および関連する代謝物を変化させる:ランダム化プラセボ対照,トリプルブラインド試験
Alonso Romo-Romo1, Mónica Sánchez-Tapia2, M Guadalupe López-Carrasco1
1Departamento de Endocrinología y Metabolismo. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Clinical nutrition ESPEN
|September 4, 2025
まとめ
人工甘味料スクラロースの摂取は,健康な個体においてインスリン感受性を有意に低下させた. これは腸内微生物群の変化と炎症の増加と関連し,グルコース代謝に影響を与える可能性があります.
科学分野:
- 代謝 健康
- 腸内微生物群の研究
- 人工甘味料の影響
背景:
- サクラロースの摂取は,インスリン感受性の低下と関連している.
- 潜在的メカニズムには腸内微生物の変化と 軽度の炎症が含まれます
研究 の 目的:
- 糖分耐性およびインスリン感受性に対するサクラロースの影響を評価する.
- 食事後のグルカゴン型ペプチド1 (GLP-1),腸内微生物群,クルリタンパク質,および代謝産物への影響を評価する.
主な方法:
- ランダム化,プラセボ制御,トリプルブラインド試験 (30日).
- 参加者はサクラロース (受容可能な日用摂取量の30%) またはプラセボを摂取した.
- 混合食事耐性試験,16S rRNA遺伝子配列化,および生化学分析が行われました.
主要な成果:
- サクラロスを摂取した後のインスリン感受性の有意な低下 (20. 3%)
- 腸内微生物のアルファ多様性が低下し,炎症誘発性マーカー,枝分かれアミノ酸 (BCAA),アセテート,糞便のCurliタンパク質が増加した.
- 血清グルタミン酸と糞便ブチラートが減少した.
結論:
- サクラロースの摂取は,健康な痩せた人のインスリン感受性に悪影響を及ぼします.
- 腸内微生物群の変化と関連する代謝物は,インスリン信号伝達に影響する炎症性状態を促進する可能性があります.
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