関連する実験動画

Updated: Sep 9, 2025

Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System
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Published on: December 28, 2017

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血小板のCOXおよびLOX酵素は,RhoAシグナル伝達によるアミロイドβ分泌をオーケストラする:神経変性疾患への影響

A Trostchansky1, M Alarcón2

  • 1Departamento de Bioquímica and Center for Free Radical and BiomedicalResearch, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.

Free radical biology & medicine
|September 4, 2025
PubMed
まとめ

血小板は,RhoAシグナル伝達によって調節されるサイクルオキシゲナーゼ (COX) とリポキシゲナーゼ (LOX) 経路を通じてアミロイドβ (Aβ) を放出する. これらの血小板経路をターゲットにすることで,神経血管性アミロイドーシスの治療の可能性が生まれます.

キーワード:
サイクロオキシゲネーゼリポキシゲネーゼアミロイドβ血小板

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