Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
Autoimmune Disorders01:29

Autoimmune Disorders

666
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
666
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

28
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
28
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

321
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
321

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Modulation of Mu-Opioid Receptor Expression and Functional Impairment of Natural Killer Cells in Neuropathic Pain: Implications for Biomarker Discovery and Personalized Therapies.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

The Dopaminergic Energy Crisis of Adolescent Depression: Mitochondrial Bioenergetics Control of Nucleus Accumbens Signaling.

Neuroscience bulletin·2026
Same author

A Biphasic Mitochondrial Damage-Management System: The Mitochondrial Derived Vescicles as Yin and Yang.

Journal of biochemical and molecular toxicology·2026
Same author

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum).

Phytotherapy research : PTR·2026
Same author

Mitochondrial dysfunction in cerebrovascular diseases.

Trends in molecular medicine·2026
Same author

The Significant Antioxidant Effect Exerted by Pomegranate (<i>Punica granatum</i>): The Hidden Polyphenols.

Antioxidants (Basel, Switzerland)·2026

関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.2K

主要免疫不全疾患,炎症,ミトコンドリア機能障害

Salvatore Nesci1, Francesca Oppedisano2, Giovanni Romeo3

  • 1Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy.

Clinical immunology (Orlando, Fla.)
|September 4, 2025
PubMed
まとめ
この要約は機械生成です。

主要免疫不全疾患 (PID) は,免疫機能の欠陥と炎症を伴う. ミトコンドリアの機能障害は これらを結びつけ 病気を誘発し 新しい治療目標を提供します

キーワード:
炎症ミトコンドリアミトコンドリアの透過性の移行孔主要免疫不全疾患mtDNA について

さらに関連する動画

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

422
Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
09:39

Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils

Published on: June 2, 2023

2.1K

関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.2K
Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

422
Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
09:39

Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils

Published on: June 2, 2023

2.1K

科学分野:

  • 免疫学
  • ミトコンドリア生物学
  • 遺伝学

背景:

  • 主要免疫不全疾患 (PID) は,免疫機能障害,感染症,自己免疫,癌を引き起こす遺伝疾患である.
  • 新興の研究では 伝統的な免疫細胞の欠陥を超えて 炎症がPIDの病原性において 重要な役割を果たしていることが明らかになっています

研究 の 目的:

  • PIDにおけるミトコンドリア機能障害と炎症の複雑な相互作用をレビューする.
  • PIDの遺伝的欠陥が 免疫ホメオスタシスを破壊し 炎症を促す方法を探る
  • ミトコンドリア経路を標的とした 治療戦略を強調する

主な方法:

  • PIDの遺伝的欠陥に関する文献レビュー
  • ミトコンドリア機能障害と炎症を結びつけるメカニズムの分析 (サイトカインの調節不全,酸化ストレス,炎症体の活性化).
  • PIDの病原性におけるミトコンドリア経路 (カルシウムシグナル伝達,ATP合成,mPTP) の探求

主要な成果:

  • PIDの遺伝的欠陥は免疫ホメオスタシスを破壊し,炎症を誘発する状態につながります.
  • ミトコンドリア機能障害,酸化ストレス,炎症は 自給自足のサイクルを形成します
  • ミトコンドリア機能の障害は,免疫不全と高炎症を結びつける中心的なメカニズムである可能性があります.

結論:

  • ミトコンドリア機能障害はPIDの病原性において重要な要因であり,免疫不全と炎症を結びつける.
  • これらの相互作用を理解することで PIDのメカニズムに関する新しい洞察が得られます.
  • ミトコンドリア経路をターゲットにすることで,PIDに対する新しい治療の機会が生まれます.