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Updated: Sep 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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ヘム酸素酵素-1 (HO-1) 減少は,卵巣がんにおけるNCOA4媒介フェリチノファギーを強化することによって,シスプラチン抵抗を逆転させるフェロプトーシスを促進する

Huan Wang1, Panpan Zhang1, Qi Cheng1

  • 1Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, 200433, Shanghai, China.

International journal of biological macromolecules
|September 4, 2025
PubMed
まとめ

ヘム酸素酶-1 (HO-1) の過剰発現は卵巣がんにおけるシスプラチン耐性を引き起こす. HO-1を阻害すると,細胞死経路であるフェロプトーシスが促進され,それによって抵抗が逆転し,新しい治療戦略が提供されます.

キーワード:
シスプラチン耐性フェリチノファジーフェロプトーシスHO-1 について卵巣がん

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