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Updated: Sep 9, 2025

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
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Published on: December 17, 2013

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周辺血清タンパク質酵素Prcは,Escherichia coliにおけるアミロイドサブユニットCsgAの分解とプロテオスタシスに関与する

Shinya Sugimoto1, Yurika Terasawa2, Naoki Tani3

  • 1Department of Bacteriology; Jikei Center for Biofilm Science and Technology; Laboratory of Amyloid Regulation, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.

Journal of molecular biology
|September 4, 2025
PubMed
まとめ

エシェリキア・コライはプロテアゼPrcを用いてクルリ亜単位CsgAを分解し,細胞内アミロイド結合を防ぐ. このプロテアゼの作用は,転写調節とともに,有害なアミロイドに対する二重の防御を形成します.

キーワード:
クルリ分子チャペロンペリプラズマプロテアゼプロテオスタシス

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