癌に関連した認知障害における運動介入:総括的なレビュー

Chen Hu¹, Yanfang Zheng, Shuyan Xing²

¹Shanxi Medical University School of Nursing, Taiyuan, 030001, Shanxi, China.

American journal of physical medicine & rehabilitation

|September 4, 2025

まとめ

運動介入はがん関連認知障害 (CRCI) を効果的に管理しますエアロビック運動は客観的な認知機能を大幅に改善し心と体の運動は癌の生存者の主観的な苦悩を軽減します

科学分野:

腫瘍学
神経科学
運動科学

背景:

癌に関連した認知障害 (CRCI) は,がんの生存者に影響する流行的で衰弱する状態です.
CRCIに対する既存の非薬理学的介入は,臨床実践を導くための堅実な証拠を必要とします.
運動はがん患者の認知障害を緩和する有望な手段です

研究の目的:

癌の生存者におけるCRCIの予防と管理のための運動介入の有効性を評価する総括的なレビューを実施する.
CRCIの臨床管理戦略に運動を組み込むための根拠に基づいた基礎を提供すること.
様々な運動様式と認知機能への影響に関する現在の証拠をまとめます.

主な方法:

癌患者の認知機能改善のための運動介入を評価する系統的レビューの事前登録された総括レビューを実施しました
AMSTAR 2を用いて,含まれた体系的なレビューの質と合成された証拠の一貫性を評価した.
エアロビック,マインド・ボディ,コンビネッド・トレーニングを含む様々な運動サブタイプを調査した28のシステマティック・レビューが含まれています.

主要な成果:

高品質のエビデンスは,有酸素運動が客観的な認知能力を大幅に改善することを支持しています (例えば,HVLT,TMT-A).
マインド・ボディ・エクササイズでは,主観的な認知的な苦情 (例えば,FACT-Cog) を減らすのに顕著な有効性が示されています.
組み合わせたトレーニングは,全体的な認知機能に初期的な相乗効果を示し,抵抗トレーニングの証拠は限られている.

結論:

運動介入は,CRCIの管理に不可欠な非薬学的な戦略です.
将来の研究は,高品質のRCT,多様式評価フレームワーク,個別化された運動ガイドラインを優先すべきです.
運動による認知機能の改善の基礎となる生物学的メカニズムを明らかにすることは精度の高い運動の処方箋に不可欠です

キーワード:

癌について癌に関連する認知障害認知能力の回復運動介入総括的なレビュー

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