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Updated: Sep 9, 2025

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans
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Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans

Published on: December 17, 2021

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アタキシン2のポリQ拡張は微小管の安定性を破壊し,軸索の増殖を阻害する

Sun K Kim1, Vladimir I Gelfand2

  • 1Northwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology Chicago, IL 60611-3008.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|September 4, 2025
PubMed
まとめ

アタキシン- 2 (ATXN2) のポリグルタミン膨張は微小管 (MT) の動態と軸索の成長を妨害し,アミオトロフィック側頭硬化症 (ALS) のリスクを高めます. この保存されたメカニズムは,ATXN2s Lsm ドメインとそのエフェクタ UNC-76 を含む.

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