血液透析患者におけるAZD1222の2回と2回のブースター接種後の細胞および体内免疫
Tsai-Chieh Ling1, Po-Lin Chen2, Jen-Ren Wang3
1Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
まとめ
AZD1222とmRNAブースターを含む4つのワクチンは,透析中の患者でOmicronのようなSARS-CoV-2の変種に対して強い免疫力を提供します. この研究では,ワクチン接種後の新しい変種に対する免疫反応を追跡した.
科学分野:
- 免疫学
- ウイルス学
- 公衆衛生
背景:
- 血液透析患者はSARS-CoV-2 (重症急性呼吸器症候群コロナウイルス2) 感染のリスクが高い.
- この脆弱な集団における新興のSARS-CoV-2変種に対するワクチン誘発免疫を理解することは極めて重要です.
研究 の 目的:
- 血液透析患者の体内および細胞の免疫反応を評価するために,COVID-19ワクチンのプライマリ・シリーズおよびブースター投与後に.
- オミクロンを含むSARS-CoV-2変種に対するワクチンの有効性を評価する.
主な方法:
- 127人の血液透析患者の観察コホート研究
- 免疫反応のモニタリング (抗SARS-CoV-2受容体結合ドメイン抗体,中和抗体,Covi-FERONアッセイ) は,第4回ワクチン接種後3ヶ月まで行われます.
- 主要およびブースター用ワクチン (AZD1222,mRNA-1273,BNT162b2) の分析
主要な成果:
- 4回のワクチン接種 (2回AZD1222, 2回mRNAブースター) で,祖先,デルタ,オミクロンBA. 1およびBA.2変異に対する抗RBD抗体および中和抗体が有意に増加しました.
- 第4回投与から1ヶ月後,高レベルの中和抗体が観察された (例えば,祖先の99%,オミクロンBA. 1の51. 5%).
- 細胞免疫 (Covi- FERON) は強い反応を示し,IL- 2とIL- 4の分泌が増加した. mRNA-1273は3回目の投与で,BNT162b2と比較して抗体の位数が高かった.
結論:
- 2回のAZD1222投与と2回のmRNAブースター投与によるワクチン接種は,血液透析患者の体内および細胞免疫を大幅に誘発する.
- この免疫は,オミクロンを含むSARS-CoV-2変種に対する保護にも及ぶ.
- mRNA-1273は有効でしたが,BNT162b2と比較して,より軽度の有害事象と関連していました.
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