前オミクロン時代を超えたシスティック線維症患者のCOVID-19:長期COVIDに特化した前向きな研究
Carla Colombo1, Paola Medino2, Marco Cipolli3
1Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
まとめ
オミクロン・フェーズにおけるCOVID-19は,一般的に軽度であり,感染後6ヶ月間には肺機能に重大な影響はなかった. 長期COVIDは5.8%の個人に発生し,大人はより持続的な症状を経験しました.
科学分野:
- 感染症
- 肺科
- 臨床医学
背景:
- 胞性線維症 (CF) 患者におけるCOVID-19の長期的な影響は十分に理解されていません.
- 大規模なCF集団における長期COVIDの発生率を評価することは極めて重要です.
研究 の 目的:
- CF患者における長期COVIDの発生率を決定する.
- 感染後のCF患者における肺機能 (FEV1) に対するCOVID-19の影響を評価する.
主な方法:
- SARS-CoV-2感染が確認された1102人の将来性,多センター研究 (2021年7月~2022年10月).
- データ収集には,感染前の状態,急性症状,入院,および症状の持続期間が含まれる.
- CDCの基準で定義された長期COVID; 6ヶ月で評価されたFEV1の変動.
主要な成果:
- COVID-19感染は,CF患者の90.1%で症状を示し,急性相合併症はまれでした.
- 感染後6ヶ月でFEV1の平均値に有意な悪影響はなかった (+1. 8%).
- 長期COVIDの発生率は5. 8%で,1. 1%が6ヶ月で持続的な症状を経験した.成人ではより頻繁な/持続的な肺外の症状があった.
結論:
- オミクロン波の間,COVID-19はCF患者において軽度な臨床経過を示し,長期的な肺機能を損ねなかった.
- 長いCOVIDは,CFを患っているすべての年齢の個人に影響しますが,大人は持続的な肺の外症状に罹患する傾向があります.
関連する概念動画
Cystic Fibrosis: Management
220
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
220
Cystic Fibrosis: Pathogenesis
358
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
358
COPD: Pathogenesis and Clinical Features
512
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
512
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K
Chronic Obstructive Pulmonary Disease
1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K


