高齢者における食事のタイミングの軌跡と,その疾患,遺伝的プロファイル,および死亡率との関連

Hassan S Dashti^1,2,3, Chloe Liu⁴, Hao Deng⁴

¹Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. hassan.dashti@mgh.harvard.edu.

Communications medicine

|September 4, 2025

まとめ

高齢者は年を取るにつれて食事の時間を遅らせて健康や長寿に影響を及ぼします遅めの朝食は病気や死亡率の増加と関連しており健康な老化のために食事のタイミングが重要であることを強調しています

科学分野:

ゲロントロジー
栄養学
クロノバイオロジー

背景:

高齢者は健康と環境要因により食事のタイミングに問題があり健康的な老化に影響します
高齢者の食事のタイミングを理解することは効果的な健康戦略の開発に不可欠です

研究の目的:

高齢者の間で自己報告された食事のタイミングの縦断的な変化を調査する.
食事のタイミング,健康状態,遺伝的要因,死亡率との関連を調べる

主な方法:

コミュニティに住む2945人の高齢者のデータを分析し,最大5回の再評価を行った.
線形混合効果モデル,潜伏クラス分析,コックス回帰を用いた.
食事のタイミング,罹病率,遺伝子プロファイル (クロノタイプ,肥満) と死亡率の関係を調べた.

主要な成果:

年齢が上がると食事の時間 (朝食,夕食) が遅くなり食事の時間が短くなります
遅い朝食のタイミングは,身体的および心理的な病気 (疲労,うつ病,多発性) の増加と関連しています.
晩のクロノタイプ遺伝子は肥満ではなく晩の食事と関連しています晩の朝食は死亡率の上昇と関連しています

結論:

食事の時間,特に朝食は年齢とともに変化し,高齢者の健康状態を反映しています.
食事のタイミングのパターンは老化人口における罹病率と長寿に影響を及ぼします
10年生存率の差異が表れているのです

さらに関連する動画

14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.0K

09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K

関連する概念動画

01:26

Aging

174

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

174

01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

123

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

123

02:20

Longitudinal Research

12.4K

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

12.4K

01:37

Mitochondria

14.8K

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

14.8K

01:19

The Effect of Aging on Tissues

2.4K

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...