妊娠糖尿病の検出基準と12〜18ヶ月の乳児の成長,栄養,神経発達:ランダム化試験における前向きなコホート研究
Francesca Amitrano1, Komal Manerkar1, Jane M Alsweiler2,3
1Liggins Institute, University of Auckland, Auckland, New Zealand.
まとめ
妊娠糖尿病 (GDM) の検出値は,乳児のアウトカムに影響します. 治療されたGDMや,より低い基準で検出された未治療のGDMは,幼児の肥満や認知障害のリスクを増加させなかった.
科学分野:
- 産婦人科
- 小児の栄養
- 発達に関する小児科
背景:
- 妊娠中の糖尿病 (GDM) は,母と乳児の健康に影響します.
- 最適なGDM検出値について議論されている.
- 幼児の発達への影響については,さらなる調査が必要である.
研究 の 目的:
- 異なるGDM検出値が乳児の成長,栄養,神経発達にどのように影響するか評価する.
- 異なる診断基準と治療状態でGDMにさらされた乳児のアウトカムを比較する.
主な方法:
- GEMS試験における前向きなコホート研究
- 妊娠中の女性はランダムにGDMの基準を低くまたは高くしました.
- 12~18ヶ月で評価された乳児のアウトカム: 体重増加/急速な増加,食欲,エネルギー摂取,認知.
主要な成果:
- 高い基準で検出されたGDMや低い基準で未治療のGDMにさらされた乳児は,より速い体重増加と潜在的に低いエネルギー摂取を示しました.
- 赤ちゃんの食欲や認知のスコアは,グループによって有意な差異は見られなかった.
- 治療されたGDM (下位の基準) に曝された乳児は,対照群に類似した.
結論:
- GDM検出の値と治療は乳児の成長軌道を左右する.
- 治療されたGDMも未治療のGDMも,低い基準で乳児肥満のリスク因子や不良認知結果が検出されました.
- 発見はGDMの診断基準が 幼児の代謝と発達経路に影響を及ぼすことを示唆しています
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