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Updated: Sep 9, 2025

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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ケトコナゾール- アディピック酸の製薬用コクリスタル: 補助物質の互換性およびインシリコ抗真菌性に関する研究

Flavia Martin1, Maria Miclaus1, Ana Maria Raluca Gherman1

  • 1National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293, Cluj-Napoca, Romania.

Pharmaceutical research
|September 4, 2025
PubMed
まとめ

ケトコナゾール- アディプ酸共結晶は,ほとんどの薬剤補助物質と良好な互換性を示し,安定性を維持し,Candida albicansに対する抗真菌活性を強化します.

キーワード:
DSC についてFTIRスペクトロシーエキシピエンスの互換性ケトコナゾール-アジプ酸共結晶分子ドッキング粉末のX線微分安定性について

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Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
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