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Updated: Sep 9, 2025

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
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Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays

Published on: February 2, 2024

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クロマチン関連 circRNA ciCRLF3 ((2) は,非同類末端結合ベースのDNA修復を活性化することによって,細胞分化阻害を調節する

Ke-Jia Pu1, Xiao-Tong Chen1, Shun-Xin Zhu1

  • 1MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Cell death and differentiation
|September 4, 2025
PubMed
まとめ

研究者らは,混合系白血病 (MLL-r) のDNA修復を調節する円形RNAを発見した. この修復を抑制し,低変異負荷のがんであるMLL- r白血病において抗癌効果を示した.

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