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Updated: Sep 9, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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喘息におけるビタミンDの不活性化を克服するためにPXRとRXRの相互作用を標的とするペプチドミメティック阻害剤のインシリコ検出

Boutaina Elgharbaoui1,2,3, E L Mehdi Bouricha4,5, Kaoutar El Guenouni2,3

  • 1Medical Biotechnology Laboratory (MedBiotech), Faculty of Medecine and Pharmacy of Rabat, Mohammed Vth University in Rabat, Rabat, Morocco.

Molecular diversity
|September 4, 2025
PubMed
まとめ

新しい分子は,喘息患者のコルチコステロイド誘発のビタミンDの損失を防ぐことができます. プレグネンX受容体 (PXR) とレチノイドX受容体 (RXR) の相互作用を抑制することで,これらの化合物は喘息の管理とビタミンDの効果を向上させることができる.

キーワード:
喘息についてCYP24A1コルチコステロイドPXR-RXR複合体ペプチドミメティックビタミンD欠乏症

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