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Updated: Sep 9, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.7K

エピタロンは,テロメラーゼのアップレギュレーションまたはALT活性により,ヒト細胞のテロメア長さを増加させる

Sarah Al-Dulaimi1, Ross Thomas1, Sheila Matta2

  • 1Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.

Biogerontology
|September 4, 2025
PubMed
まとめ

エピタロンは,テロメラーゼ活性とhTERT発現を高めることで,哺乳類の細胞のテロメア長さを延長します. このペプチドはまた,がん細胞におけるテロメアの代替延長を活性化させ,健康的な老化とがん研究の可能性を示唆する.

キーワード:
ALTについて哺乳類の細胞テロメラーゼテロメア長さ

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