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Updated: Sep 9, 2025

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Selena J An1, Christine Hong Ngoc Che Thai1, Chris B Agala1,2

  • 1Department of Surgery, University of North Carolina, Chapel Hill, NC, USA.

Annals of surgical oncology
|September 4, 2025
PubMed
まとめ

No abstract available in PubMed .

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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