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新型抗キット抗体薬結合体NN3201の臨床前抗腫瘍効果

Chansik Kim1, Jinwoo Park1, Jin-Ock Kim1

  • 1Novelty Nobility, Seongnam-si, Korea (South), Republic of.

Molecular cancer therapeutics
|September 5, 2025
PubMed
まとめ

新型抗体- 薬物結合体NN3201は,変異に関係なく,SCLCやGISTのようなc- Kit陽性がんに対する有意な抗腫瘍活性を示しています. 臨床前試験では好ましい安全性を示した.

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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