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Updated: May 11, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
10:20

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

8.6K

Fmr1ノックアウトは,背中側タラモコルチカルニューロンのHCNチャネル活性低下によって,複数の内在的特性を破壊する

Gregory J Ordemann1,2, Polina Lyuboslavsky1,2, Alena Kizimenko1,2

  • 1Department of Neurology, Dell Medical School at The University of Texas at Austin, Austin, Texas, USA.

Experimental physiology
|September 5, 2025
PubMed
まとめ

マウスの脆弱X症候群 (Fragile X syndrome,FXS) は,前頭前皮質に発射する中背のタラムスのニューロンのHCNチャネル機能を損なう. この障害は神経のリズムに 影響を及ぼし 認知や社会的行動に 影響を及ぼします

キーワード:
HCNチャネル脆弱なX症候群本質的な特性背中タラムス前頭皮質スパイクタイムタラモコルチカル不律症

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Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

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Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation11:10

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation

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Nucleosome Remodeling

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NF-κB-dependent Signaling Pathway

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Export of Misfolded Proteins out of the ER

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NF-kB-dependent Signaling Pathway

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