関連する実験動画
Updated: Sep 9, 2025

07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.4K
スペーストランスクリプトミクスは,甲状腺がんの分化中にトランスクリプトミクスの再プログラムと免疫マイクロ環境を明らかにする
Kang Ning1,2,3, Bu Zou1,2,3, Yongchao Yu1,2,3
1Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 5, 2025
まとめ
アナプラスティック甲状腺癌 (ATC) は,ゲノム変化と免疫抑制によって,差別化甲状腺癌 (DTC) から進化する. PDCD4の喪失は,ATCの進行に不可欠な,腫瘍に関連したマクロファージの浸透を誘発する.
科学分野:
- 腫瘍学
- ゲノミクス
- 免疫学
背景:
- アナプラスティック甲状腺癌 (ATC) は極めて致命的な悪性腫瘍です.
- ATCは,よく分化性甲状腺がん (DTC) から生じるが,その分化過程はよくわかっていない.
研究 の 目的:
- DTCからATCへの移行を促す分子メカニズムを解明する.
- 甲状腺がんの分化における 重要なレギュレータと細胞を特定する.
主な方法:
- Spatial transcriptomic sequencing (spRNAseq) は,共存するDTCとATC領域について行われます.
- 全エクソムのシーケンシングとCNV分析を推論する.
- 軌道分析とメカニズム実験
主要な成果:
- ATCは免疫抑制,血管新生,ECMリモデリング遺伝子を上位に調節している.
- 隣接するDTC領域は 早期のゲノム変異を示し 脱差を促しています
- PDCD4とTYMPは,甲状腺がんの分化における重要な調節因子である.
- TYMP+腫瘍関連マクロファージ (TAMs) はATCに富み,免疫抑制を促進する.
- PDCD4の喪失は,eIF4Aに依存する経路経由でTAMの浸透を促進する.
結論:
- ATCのようなゲノム変異を持つDTCは,ATCになるために,トランスクリプトミアと免疫再プログラムを受けます.
- PDCD4喪失によるTAM形成は,ATCの発達と進行にとって極めて重要です.
関連する概念動画
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
The Thyroid Gland
4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Forced Transdifferentiation
2.0K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
2.0K

