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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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スペーストランスクリプトミクスは,甲状腺がんの分化中にトランスクリプトミクスの再プログラムと免疫マイクロ環境を明らかにする.

Kang Ning1,2,3, Bu Zou1,2,3, Yongchao Yu1,2,3

  • 1Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

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PubMed
まとめ
この要約は機械生成です。

アナプラスティック甲状腺癌 (ATC) は,ゲノム変化と免疫抑制によって,差別化甲状腺癌 (DTC) から進化する. PDCD4の喪失は,ATCの進行に不可欠な,腫瘍に関連したマクロファージの浸透を誘発する.

キーワード:
M2 マクロファージPDCD4 についてアナプラスティック甲状腺がん分化甲状腺がん空間トランスクリプトミクス

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科学分野:

  • 腫瘍学
  • ゲノミクス
  • 免疫学

背景:

  • アナプラスティック甲状腺癌 (ATC) は極めて致命的な悪性腫瘍です.
  • ATCは,よく分化性甲状腺がん (DTC) から生じるが,その分化過程はよくわかっていない.

研究 の 目的:

  • DTCからATCへの移行を促す分子メカニズムを解明する.
  • 甲状腺がんの分化における 重要なレギュレータと細胞を特定する.

主な方法:

  • Spatial transcriptomic sequencing (spRNAseq) は,共存するDTCとATC領域について行われます.
  • 全エクソムのシーケンシングとCNV分析を推論する.
  • 軌道分析とメカニズム実験

主要な成果:

  • ATCは免疫抑制,血管新生,ECMリモデリング遺伝子を上位に調節している.
  • 隣接するDTC領域は 早期のゲノム変異を示し 脱差を促しています
  • PDCD4とTYMPは,甲状腺がんの分化における重要な調節因子である.
  • TYMP+腫瘍関連マクロファージ (TAMs) はATCに富み,免疫抑制を促進する.
  • PDCD4の喪失は,eIF4Aに依存する経路経由でTAMの浸透を促進する.

結論:

  • ATCのようなゲノム変異を持つDTCは,ATCになるために,トランスクリプトミアと免疫再プログラムを受けます.
  • PDCD4喪失によるTAM形成は,ATCの発達と進行にとって極めて重要です.