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Updated: Sep 8, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

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γδ T 細胞からの溶性セマ4Dは,プレキシン-B/mTORシグナル伝達を通じて骨質細胞の阻害を引き起こし,ビスホスフォナート関連の骨神経症の病原化に寄与する

Lingling Ou1,2, Shijia Qiao2, Zhuoyi Liao1

  • 1School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China.

Cell proliferation
|September 5, 2025
PubMed
まとめ

ガンマ・デルタ・T細胞は骨形成を抑制することで,ビスフォスフォナート関連の骨縮症 (BRONJ) を悪化させる. これらの細胞を枯渇させたり 新しいヒドロゲル療法を使うことで BRONJの病変が減少し 新しい治療戦略が生まれました

キーワード:
ブロンズMMP3 についてセマ4Dゲル-BG@abγδ T細胞

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Osteoclasts in Bone Remodeling

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