人間のがんにおける長い非コーディングRNAVPS9D1-AS1:機能,メカニズム,および臨床的有用性
Jingjie Yang1,2, Haodong He1,2, Haoran Liu1,2
1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China.
Anti-cancer agents in medicinal chemistry
|September 5, 2025
まとめ
VPS9D1-AS1は,新しい長い非コーディングRNAであり,多くのがんにおいて高い発現率を持ち,予後不良と関連しています. 腫瘍の進行を促す信号や 支柱や 誘導体として機能します
科学分野:
- 腫瘍学
- 分子生物学
- 遺伝学
背景:
- VPS9D1-AS1は,MYUまたはFAISLとしても知られる,人間の染色体16q24.3に位置する長い非コーディングRNA (lncRNA) である.
- この lncRNA は様々なヒトの癌で過剰に発現することが多い.
- 高VPS9D1- AS1発現は,不良な臨床病理的特徴と,複数の悪性腫瘍の予後不良と相関する.
研究 の 目的:
- 癌におけるVPS9D1-AS1の分子メカニズムと腫瘍学的役割を調査する.
- 腫瘍の発達と進行におけるVPS9D1-AS1の機能に関する現在の理解を要約する.
主な方法:
- PubMed,Web of Science,Google Scholarで広範な文献検索が行われました.
- 含まれる研究は,腫瘍学におけるVPS9D1- AS1 (MYU,FAISL) に焦点を当てたピアレビュー出版物であった.
主要な成果:
- VPS9D1-AS1は 信号,脚架,誘導体,誘導体として機能する
- これらの役割により,VPS9D1-AS1は標的遺伝子発現とシグナル伝達経路を調節することができます.
- その機能は,増殖,侵入,転移を含む腫瘍の悪性現象型に寄与する.
結論:
- VPS9D1-AS1は,様々な癌の発生と進行における重要な調節因子です.
- 多面的な分子メカニズムは 腫瘍生物学における その重要性を強調しています
- VPS9D1-AS1に関するさらなる研究は,新しいがん診断および治療戦略につながる可能性があります.
関連する概念動画
lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
Loss of Tumor Suppressor Gene Functions
5.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.1K
Rous Sarcoma Virus (RSV) and Cancer
5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.4K
Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Non-LTR Retrotransposons
11.8K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.8K


