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関連する概念動画

Drug Delivery: Overview01:16

Drug Delivery: Overview

411
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
411
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

466
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
466
Drug Regulation01:25

Drug Regulation

1.8K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.8K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

821
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
821
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

706
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
706
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

737
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
737

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Updated: Sep 9, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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2019年から2023年までUSFDAが承認した新薬配達システム:包括的なレビュー

Anfal F Almazyad1, Nazrul Haq2, Ibrahim A Alsarra2

  • 1Joint Program Council in Drug Regulatory Affairs, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Current drug delivery
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まとめ

新薬投与システム (NDDS) の最近の進歩は,米国食品医薬品局 (USFDA) の承認につながり,薬の有効性と患者の快適性を高めています. このレビューは,2019年から2023年にかけての NDDS の主要イノベーションをまとめています.

キーワード:
抗体薬の結合体アメリカ食品医薬品局ブロックコポリマーミセル販売されている製品新薬投与システムパテント

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Last Updated: Sep 9, 2025

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科学分野:

  • 医薬品科学
  • バイオテクノロジー
  • 薬物投与技術

背景:

  • 新薬投与システム (NDDS) は,治療結果と患者の服従を改善するために不可欠です.
  • NDDSの重要な進展は,最近の規制承認の見直しを必要としています.
  • 承認されたNDDSを理解することは,将来の医薬品の革新にとって不可欠です.

研究 の 目的:

  • 2019年から2023年まで,米国食品医薬品局 (USFDA) が承認したNDDSを包括的に検討する.
  • これらのNDDSを投与経路 (経口,注射,皮膚経由など) によって分類し,分析する. ) でした.
  • 承認されたNDDSのメカニズム,利点,制限,臨床応用,および将来の見通しについて議論する.

主な方法:

  • PubMed,Scopus,USFDAのデータベースや特許のウェブサイトで 文献検索を行いました
  • 投与経路に基づいて承認されたNDDSの体系的なレビューと分類.
  • 行動のメカニズム,利点,制限を含む各NDDSの詳細な分析.

主要な成果:

  • 2019年から2023年の間に複数の革新的なNDDS技術がUSFDAの承認を受けました.
  • 承認されたNDDSは,薬剤の安定性,生物学的利用可能性,および制御された放出を示す.
  • これらのシステムは 治療効果の向上と 患者の快適さを 提供する様々な経路で提供します

結論:

  • 2019年から2023年の間,米国食品医薬品局 (USFDA) の承認により,NDDSの大幅な進展が見られました.
  • 承認されたNDDSは,薬物製剤と投与戦略の重要な進歩を表しています.
  • このレビューは,患者中心の薬物投与における将来の研究開発の指針として貴重なリソースとして機能します.