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Updated: Sep 9, 2025

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress
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Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress

Published on: August 2, 2019

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危険信号としてのシェア・ストレスは,メカノセンシティブ・ネトーシスによる炎症と血栓形成を引き起こします

Sara Baratchi1,2,3, Karlheinz Peter1,2

  • 1Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

BioEssays : news and reviews in molecular, cellular and developmental biology
|September 5, 2025
PubMed
まとめ

中性粒子の細胞外トラップ (NETs) は中性粒子が放出し,炎症や血栓形成を引き起こす可能性があります. ピエゾ1のようなチャネルを通して 切断ストレスのような機械的な力が NETosisを誘発し 血管疾患に影響を与えます

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Shearing Stress01:19

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
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Cell-matrix's Response to Mechanical Forces

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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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Shearing Strain01:20

Shearing Strain

The shearing strain represents a cubic element's angular change when subjected to shearing stress. This type of stress can transform a cube into an oblique parallelepiped without influencing normal strains. The cubic element experiences a significant transformation when exposed solely to shearing stress. Its shape alters from a perfect cube into a rhomboid, clearly demonstrating the effect of shearing strain. The degree of this strain is considered positive if it reduces the angle between...
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Inflammation

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