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Updated: May 5, 2026

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation
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MiR-146b-5pは,アストロサイトからのサイトカインの放出を減らし,炎症中にオリゴデンドロサイト原始細胞の複合性を維持する

Cassandra E Thompson1, Sheila Loshi1, Samantha J Carew1

  • 1Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

The European journal of neuroscience
|September 5, 2025
PubMed
まとめ

この研究では,アストロサイトにおけるmiR- 146b- 5pの増加は,炎症を軽減し,多発性硬化症 (MS) モデルにおけるオリゴデンドロサイト原始細胞 (OPC) の修復を促進します. これは,miR-146b-5pを,MSの潜在的な治療標的として強調しています.

キーワード:
アストロサイトmiR‐146b‐5pマイクロRNAマイクログリア多発性硬化症オリゴデンドロサイト原始細胞

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