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Updated: Sep 9, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

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ハイドロコドンとCYP3A4を阻害するカルシウムチャネルブロッカーの同時使用に関連したオピオイド過剰摂取のリスク:集団ベースのコホート研究

Sungho Bea1,2, C Andrew Basham1, Heba H Edrees1

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

American journal of epidemiology
|September 5, 2025
PubMed
まとめ

サイトクロームP450 3A4 (CYP3A4) を阻害する非ディヒドロピリジンカルシウムチャネル阻害剤 (CCB) は,ヒドロコドンと共に使用された場合,オピオイドの過剰投与リスクを増加させません. この発見は,CCBを服用している間にヒドロコドンを開始することと,ヒドロコドンを服用している間にCCBを開始することの両方に適用されます.

キーワード:
カルシウムチャネルブロッカー薬物相互作用ハイドロコドンオピオイドの過剰摂取薬学流行病学集団ベースのコホート研究

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