炎症指標をpTNM-炎症ステージシステム (pTNM-I) に統合することにより,胃がんの予後改善
ZhanShuo Liu1, Hao Liu2, Yue Zhang3
1Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Journal of inflammation research
|September 5, 2025
まとめ
新しいpTNM-Inflammation (pTNM-I) ステージングシステムは,炎症マーカーを組み込むことで胃がんの予後を改善します. この改良されたシステムは,従来のpTNMの段階比より優れた患者分層化を可能にします.
科学分野:
- 腫瘍学
- 外科病理学
- 癌 の ステージ
背景:
- 胃がん (GC) の病理性腫瘍ノード転移 (pTNM) ステージングシステムは,予後差別に制限があります.
- 外部炎症マーカーは,GC患者に対する予後情報を提供することができる.
- GCにおける予後分層化の改善が必要である.
研究 の 目的:
- 胃がんのための新しいpTNM-炎症 (pTNM-I) ステージングシステムを開発する.
- 末端炎症状態とpTNMのステージ化を統合して,予後分層化を改善する.
- pTNM-Iシステムの予測性能を,従来のpTNM段階化と比較して評価する.
主な方法:
- 治癒手術を受けた4,049人のGC患者の遡及分析.
- 中性細胞対リンパ球比 (NLR),血小板対リンパ球比 (PLR),全身免疫炎症指数 (SII) の最適切断値の決定
- pTNM-I段階化システムとノモグラムの構築;カプラン・マイヤー曲線とコックス回帰分析を用いた評価.
主要な成果:
- pTNM- I分期システムは,I- aからIII- cまでの5年生存層を有意に改善した (P < 0. 001).
- pTNM- Iは,pTNM段階測定と比較して優れた予測能力を示した (AUC: 0. 798 対 0. 743).
- pTNM- Iは独立した予後因子として特定され,pTNM- Iベースのノモグラムはより良い予測性能を示した (AUC: 0. 808 対 0. 743).
結論:
- pTNM-Iステージングシステムは,胃がんに対するより堅固な予後判別能力を提供します.
- このシステムは,炎症マーカーをGCステージに効果的に統合します.
- pTNM-Iシステムは,GCの予後における臨床応用のためのシンプルで,経済的かつ貴重なツールです.
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