COVID-19 と 血管新生の関連性: 体系的なレビュー
Mohamed Zahed1, Alzahraa Faris Alesawy2, Ziad Samir Zahed3
1Orthopedics, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, GBR.
Cureus
|September 5, 2025
まとめ
血管性死滅 (AVN) はCOVID-19とステロイド使用に関連しています. このレビューは関連性を確認し,患者のコルチコステロイド処方とAVNモニタリングの必要性を強調しています.
科学分野:
- 整形 科 と 感染症
- ウイルス感染症の肺外合併症の調査
- 病理学と薬理学
背景:
- 血管死 (AVN) は,COVID-19感染後の合併症としてますます認識されています.
- COVID-19にしばしば使用されるコルチコステロイド療法は,AVNの既知の危険因子である.
- この関連性を理解することは 患者の管理に極めて重要です
研究 の 目的:
- COVID-19 とコルチコステロイドの使用,および AVN の発症との関連を体系的に検討し評価する.
- この新たな合併症に関する既存の文献の証拠を統合する.
- リスク軽減に関する臨床実務を伝えるため
主な方法:
- 2024年5月30日までの5つのデータベースを検索し,PRISMAのガイドラインに準拠したシステマティック・レビュー.
- AVNと診断されたCOVID-19患者のコホートおよびケースシリーズ研究を含む.
- バイアスのリスクは,ニューカッスル・オタワスケール (NOS) を用いて評価する.
主要な成果:
- 795人の患者を対象とした13件の研究 (9件の症例シリーズ,4件のコホート) が含まれた.
- 股関節と股関節の頭部が 最も影響を受けた部位でした
- COVID-19 と,コルチコステロイドの使用,および AVN の発症との間に有意な関連性が確認されました.
結論:
- COVID-19とコルチコステロイドの使用は,無血管性死滅の発生と有意に関連しています.
- 臨床医は,特にCOVID-19後に,コルチコステロイドで治療された患者のAVN症状に注意する必要があります.
- AVNのリスクを減らすために,病理学と代替治療に関するさらなる研究が必要である.
さらに関連する動画
05:55Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
Published on: September 27, 2024
665
04:30Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
3.4K
関連する概念動画
01:29Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
01:29Blood and Nerve Supply to the Bones
11.8K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
11.8K
01:27Fractures: Bone Repair
3.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.6K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.4K
01:25Role of Vitamins in Maintaining Bone Health
3.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.6K
01:31Osteoclasts in Bone Remodeling
3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K