健康な成人の腸内微生物と血代謝に低乳糖,高ギャラクトオリゴサッカライドの影響: ランダム化,ダブルブラインド,制御された臨床試験
Léa Siegwald1, Anna Cherta-Murillo1, Stefan Christen2
1Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Current developments in nutrition
|September 5, 2025
まとめ
新鮮な牛乳は プリバイオティックなガラクタ・オリゴサカリド (GOS) が豊富で 健康な成人の腸内バイフィドバクテリアを 大きく増やしました この介入は,免疫と代謝の健康改善に関連した血代謝を変化させました.
科学分野:
- 微生物群の研究
- 人間の栄養
- メタボロミクス
背景:
- ガラクトオリゴサッカライド (GOS) は腸内微生物群を調節し,健康に有益です.
- ノベルミルク (Nミルク) は乳糖を減らす乳製品で,プレバイオティックGOSの含有量が高い.
- 乳は栄養価を保ちながら プリバイオティクスを提供します
研究 の 目的:
- Nミルクが腸内微生物に与える影響を調べる
- Nミルク摂取後の健康関連のバイオマーカーの変化を評価する.
- 臨床的発見はex vivo発酵研究で補完する.
主な方法:
- 26人の健康な成人を対象に ランダム化され,二重盲検試験を実施した.
- 参加者は2週間,Nミルクまたは乳糖のない対照ミルクを摂取した.
- ショットガンメタゲノミクスとプラズマメタボロミクスによる腸内微生物群分析
主要な成果:
- N 乳の摂取は腸内バイフィドバクテリアを3倍に増加させた (P < 0. 0001).
- プラズマアセテート,オクタノ酸,β - アラニン,ニコチナミドの有意な増加が観察されました.
- Nミルクはアミノ酸代謝を変化させ,尿中の毒素を減少させ,トリプトファンの代謝を変化させた.
結論:
- 牛乳の消費は腸内バイフィド菌群を 大きく増やします
- プラズマ代謝産物の変化は,免疫的および代謝的健康上の利点の可能性を示唆しています.
- 腸内細菌と代謝産物に対する 独特の効果が確認されました
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