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Updated: Sep 9, 2025

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

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Published on: May 2, 2018

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オマダサイクリン治療の圧力下で同じ源から発生したカルバペネム耐性クレブシエラ肺炎の毒性の進化

Jianhua Fang1,2, Qiong Liu3, Huade Chen1,2

  • 1Jiangxi Provincial Key Laboratory of Prevention and Treatment of Infectious Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330052, People's Republic of China.

Infection and drug resistance
|September 5, 2025
PubMed
まとめ

カーバペネム耐性Klebsiella pneumoniae (CRKP) は,抗生物質の圧力下でその毒性を適応させることができる. この適応的進化において,terW遺伝子は重要な役割を果たし,CRKPに影響を与えます.

キーワード:
CRKP についてクレブシエラ・プネモニアオマダサイクリンテール毒性について

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
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Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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