関連する実験動画

Updated: Sep 9, 2025

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

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ヒトのCD4+T細胞におけるmRNAの安定性とサブセルラー分布を調節するケモカイン受容体CCR2とhnRNPA0の3'-UTRの役割

Yunus Yukselten1, Hanan Wishah1, Lingyun Wang1

  • 1Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, United States.

Frontiers in immunology
|September 5, 2025
PubMed
まとめ

CCR2 3'-UTRは,この領域にHnRNPA0を結合させ,遺伝子発現を著しく抑制する. 3'-UTRを除去すると,CCR2レベルが上昇し,炎症性および感染症の新たな標的となる.

キーワード:
CCR2 3-UTRCRISPR-Cas9 KOについてR5熱性HIV共受容体RNA結合タンパク質hnRNPA0 についてトランスクリプション後の調節

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