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Updated: Sep 9, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Published on: January 31, 2018

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染色体とDNAの断裂に対する核素解封とPARP1アロステリー駆動の親和性

Matthew A Schaich, Tyler M Weaver, Jennifer A Rakowski

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    まとめ

    ポリ[ADP-リボース]ポリメラーゼ1 (PARP1) は,ナノモラー親和性を持つDNAニークを結合する. PARP1は,無傷の核素核粒子を結合し,結合はDNAの張力によって強化され,触媒死 PARP1によって抑制されます.

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