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Updated: Sep 9, 2025

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Hand Dissection of Caenorhabditis elegans Intestines
Published on: September 13, 2022
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Tabula Sapiens は,28 の 人体 の 臓器 や 組織 の 細胞 型 の 中 で,転写 因子 の 発現,老化 効果,および 性別 特定 の 特徴 を 明らかに し て い ます
bioRxiv : the preprint server for biology
|September 5, 2025
まとめ
Tabula Sapiens 2.0はヒトの細胞アトラスを拡張し 細胞数と新しい組織を2倍にしました この包括的なデータセットは,転写因子,細胞老化,ヒト臓器における性特異的な遺伝子発現に関する新しい洞察を提供します.
科学分野:
- ゲノミクス
- 細胞生物学
- バイオ情報学
背景:
- Tabula Sapiens プロジェクトは,ヒト細胞の包括的な単細胞トランスクリプトミックの参照アトラスを提供しています.
- 以前のバージョンは組織間の細胞異質性を理解するための基盤を確立しました.
研究 の 目的:
- Tabula Sapiensのヒト細胞アトラスを新しいドナーと組織で大きく拡張する.
- 転写因子発現,細胞老化,および性特異的な遺伝子発現パターンを分析する.
- ドナーの健康歴を調査するためのアクセシブルなツールを開発する.
主な方法:
- 複数の臓器と組織からの単細胞RNAの配列化
- 転写因子発現,老化マーカー,性バイアス遺伝子発現のバイオ情報分析
- 大規模な言語モデル駆動のウェブアプリケーションの開発
主要な成果:
- Tabula Sapiens 2.0は細胞数を2倍にし,制御された比較のために多臓器ドナーを含む新しい組織を追加します.
- ほぼすべてのヒトの転写因子の推定的な細胞型特異性と調節作用が特定された.
- 細胞老化の普遍的および臓器/細胞タイプ特有の属性は明らかにされた.
- 異なる性特有の遺伝子発現プロファイルが様々な細胞タイプで発見されました.
- 提供者の健康記録をインタラクティブに検索するための Web アプリケーションが作成されました.
結論:
- ヒトの細胞アトラスの資源における大きな進歩を 表しています
- 拡張されたデータセットは,ヒト細胞の遺伝子調節,老化,性差の研究に前例のない解像度を提供します.
- 統合された分析は,多様なヒト細胞の基本的生物学的プロセスに関する基礎的な洞察を提供します.
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