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Updated: Sep 9, 2025

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

12.6K

HP1βとH3K9me3は嗅覚受容体選択と転写的アイデンティティを調節する

Martín Escamilla-Del-Arenal, Rachel Duffié, Hani Shayya

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    まとめ

    ヘテロクロマチンタンパク質1β (HP1β) は嗅覚神経細胞 (OSN) の多様性にとって不可欠である. HP1βをHP1αに置き換えると,遺伝子発現が妨げられ,嗅覚受容体 (OR) のレパートリーが減少し,神経のアイデンティティが損なわれます.

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    Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor10:16

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    General Transcription Factors01:30

    General Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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    Master Transcription Regulators02:23

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    In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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    The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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