関連する実験動画

Updated: Sep 9, 2025

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

5.2K

マルチロカス配列型17株におけるCRISPR干渉

William D Cutts, Aidan W Flanagan, Brice Gorman

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    まとめ

    研究者らは,グループBのストレプトコッカス (GBS) ST-17菌株に対するCRISPR干渉システムを開発した. このツールは,血脳障壁のGBS髄膜炎の病原性を研究するために,標的の遺伝子ノックダウンを可能にします.

    さらに関連する動画

    Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins10:46

    Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

    Published on: October 18, 2022

    1.8K
    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein05:48

    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

    Published on: March 16, 2022

    2.7K

    関連する概念動画

    CRISPR and crRNAs02:53

    CRISPR and crRNAs

    Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
    The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
    17.3K
    The Antiviral System of Bacteria and Archaea: CRISPR01:23

    The Antiviral System of Bacteria and Archaea: CRISPR

    CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
    121
    CRISPR/Cas9 Genome Editing01:28

    CRISPR/Cas9 Genome Editing

    The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
    208
    CRISPR01:59

    CRISPR

    Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
    52.8K
    Conservative Site-specific Recombination and Phase Variation02:53

    Conservative Site-specific Recombination and Phase Variation

    Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
    The recognition sites for Cre recombinase called LoxP...
    6.1K