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Updated: Sep 9, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

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T細胞のBCL6は,インスリン自己反応性Bリンパ球の運命をリダイレクトすることによって1型糖尿病を促進する

Landon M Clark, Jack C McAninch, Dudley H McNitt

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    まとめ

    BCL6をT細胞に標的にすることで,病原性B細胞の活性が低下することで,タイプ1糖尿病から保護されます. この発見は,自己免疫が始まっても,BCL6抑制を1型糖尿病の潜在的な免疫療法として支持する.

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