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Updated: Sep 9, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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TP53変異は,ミトコンドリアカスパースブロックによる治療抵抗を誘発する

Ahmed M Mamdouh, Elyse A Olesinski, Fang Qi Lim

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    まとめ

    急性骨髄性白血病 (AML) のTP53変異は,ミトコンドリアの浸透を阻害するのではなく,カスパースの活性化を阻害することで,VenAza治療に対する耐性を引き起こします. この発見は,TP53変異性AMLにおける治療抵抗性を克服するための新しい治療目標を示しています.

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