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Updated: Sep 9, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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RAFの抑制後のARF6の急速な活性化は,BRAFV600Eを増加させ,治療に対する耐性を促進する

Allie Grossmann, Junhua Wang, Yinshen Wee

    Research square
    |September 5, 2025
    PubMed
    まとめ

    小さなGTPase ARF6はBRAFオンコタンパク質の発現を促進し,がん細胞の生存と薬剤耐性を促進する. ARF6を阻害することは,BRAF V600Eの癌に対する新しい治療戦略を提供することができる.

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    Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines10:16

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