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Updated: Sep 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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肝臓のフェルドキシン還元酵素は,代謝機能不全に関連したステアトーシス肝疾患において,ミトコンドリア機能と鉄の恒常性を調節する

Tomoaki Tanaka, Ikki Sakuma, Rafael Gaspar

    Research square
    |September 5, 2025
    PubMed
    まとめ

    フェルドキシン還元酵素 (FDXR) 欠乏症は,ミトコンドリア機能を低下させ,鉄分を増やすことにより,代謝機能不全に関連した脂肪性肝疾患 (MASLD) を悪化させる. MASLDにおけるアップレギュレーションされたFDXRは,その回復が肝臓ステアトーシスを改善することで,保護的な役割を果たすことを示唆している.

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